A letter to those suffering from Fibromyalgia and CFS

From:  Dr. Rodger H. Murphree


September, 2004

Chronic Pain and Fibromyalgia

The diffuse muscle pain associated with fibromyalgia can be debilitating. Unless you’ve experienced the achy all-over pain that accompanies fibromyalgia you can’t imagine the amount of discomfort, stress, and fatigue it creates. For those people who don’t know what fibromyalgia is like, I ask them to imagine waking up everyday with the "flu from hell."

The pain can become worse when the individual gets under more stress (depleting serotonin), the weather changes, and after being on certain prescription medications for extended periods of time (Ambien).

I’d always been healthy until my car accident 10 years ago. Immediately after my wreck I was taken to the emergency room. I had broken 2 neck bones. The doctors said there wasn’t much they could do but prescribe muscle relaxants, anti-inflammatory medications, and pain pills. For the next 2 months I had a splitting headache everyday. These finally went away (saw numerous doctors), but my neck pain didn’t. I was miserable. I couldn’t sleep at night and felt terrible every day. Then I started getting back and leg pains. All my x-rays were normal. Pain pills didn’t help at all. Weather changes made my pain worse. And if I got under any stress I would be wiped out for days. I developed IBS, carpal tunnel, and low thyroid (hair loss, dry skin, depressed, and weight gain) over the next year. None of the medications I take help. I’m on Ultram, Neurontin, Celebrex, Flexeril, Paxil, Prevacid, and Klonopin. I feel like a zombie most of the time. I had to quit working. I couldn’t believe this could happen to me. I’m only 40 years old. I used to be so healthy. Tara Reid


Pain may arise from wear-and-tear arthritis (osteoarthritis), scar tissue, lactic acid (trigger points), allergic reactions, leaky gut, intestinal dysbiosis (yeast overgrowth), nightshade sensitivity, autoimmune disorders (rheumatoid arthritis), low serotonin levels or poor detoxification processes. Finding and successfully treating the source of chronic pain can be difficult.

Pain is initiated from inflammatory chemicals that are released in response to injury. Pain acts as an alarm to warn us of potential danger. If you’ve ever placed your hand on a hot stove, you know pain acts as a potent deterrent to not make this mistake twice. Wherever there is pain, there is inflammation. Inflammation is a normal and important, bodily reaction. Inflammation allows the body to attack unwanted invading microorganisms (viruses, bacteria, etc.), remove damaged cells (from injury), eliminate toxins, and is part of the body’s repair process.

How the inflammatory system works

Trauma, infection, ischemia (reduced blood flow), toxins, poisons, and normal wear and tear cause damage and destruction to cells. This damage then triggers an orderly inflammatory response by the body’s self-regulating mechanisms. When cells become damaged, they release special enzymes. These enzymes digest the parts of the cell that have been damaged. If the damage is minor, the cell can repair itself. If the damage is severe, the entire cell is digested (autolysis) and a new cell is made. If a lot of cells (tissue) are damaged, either by trauma (sprained ankle, back joint, etc.) or autolysis (cell death from toxic exposure, radiation, etc.), certain chemicals are released into the surrounding tissues, producing inflammation and more pain.

Inflammatory chemicals

The first group of chemicals, histamine, leukotriens, and pro-inflammatory hormones (prostaglandins), cause the blood vessels to dilate or expand. The dilation of the blood vessels causes the area to become hot, red and swollen. The dilated vessels (capillaries) allow needed nutrients and white blood cells to get to the damaged (swollen) area.

The white blood cells are charged with digesting and removing damaged cells (phagocytosis). These white blood cells gobble up everything in sight. Foreign invaders or pathogens (viruses, allergens, free radicals, etc) release their own chemicals, many of which are toxic. The healthy tissue surrounding the damaged area releases anti-inflammatory prostaglandins (PG1 and PG3) to combat the inflammatory prostaglandins (PG2). Certain chemicals (proteolytic enzymes) are responsible for telling the white blood cells that their job is done. These chemicals sound the alarm for the white blood cells to stop attacking and digesting cells and tissues.

*Proteolytic enzymes are manufactured to squelch the white blood cells from continuing to eat up cellular debris. As the damaged cells and tissues are removed, less of the pro-inflammatory chemicals and more of the anti-inflammatory chemicals are released. Once the inflammation process is finished, the body begins to repair itself.

The balance between inflammation, destruction, and repair is an ongoing process. Normally, this process is kept in check. When the process becomes unbalanced, chronic inflammation takes over.

Inflammation is largely regulated by the prostaglandin hormones mentioned above.


Prostaglandins are a group of regulatory hormones produced in the body from fatty acids. There are several different groups of prostaglandins, but inflammation is largely controlled by Prostaglandin 1 (PG-1), Prostaglandin 2 (PG-2), and Prostaglandin 3 (PG-3).

PG-1, PG-2, and PG-3 are produced from essential fatty acids.

Essential fatty acids are essential for our existence. They can’t be manufactured by the body but must be obtained from the foods we eat. Essential fatty acids are made-up of polyunsaturated fatty acids (PUFAs).

PUFAs are divided into two families of essential fatty acids (EFA).

PUFAs are further broken down into Omega 3 (fish oils) and Omega 6 (vegetable oils).

Anti-inflammatory hormones

PG-1 and PG-3 come mainly from Omega 3 oils (fish oils) and are anti-inflammatory hormones. They help reduce and eliminate inflammation and pain.

Arachidonic Acid (AA) PG-2 Causes Pain and Inflammation

AA is an essential fatty acid (EFA) in the Omega 6 family. AA is found in corn and corn oil products. Corn products are used as the prominent foodstuff in westernized livestock. Red meat, dairy, and pork products have a high AA content.

The pro-inflammatory series PG-2 are made from arachidonic acid. Arachidonic acid is derived from the consumption of land animal foods (meats, cheese, eggs, etc.). Arachidonic acid stimulates the production of inflammatory chemicals including leukotriens (notorious in causing allergic reactions), thromboxanes, and prostacylins. Several research articles have demonstrated that the more animal fats a human eats, the more arachidonic acid they have in their blood and cell membranes and the more likely to have inflammation.

Conversely, a diet high in fish or supplemented with fish oil (EPA) helps reduce inflammation.

A. Omega 3 Linolenic Acid

Omega 3 oils include are found in flax seed, soybean, walnut, and chestnut oils, as well as some dark green leafy vegetables.  Eicosapentaenoic Acid (EPA) and DHA (docosahexanoic acid) are Omega 3 derivatives and are only found in cold water fish. These fish include salmon, tuna, and mackerel

The average AA (PG-2 from vegetable oils and animal products) to EPA (PG-1 and PG-3 from fish oils) of Americans is approximately 11:1. For patients with inflammatory conditions and neurological disorders, the AA/EPA ratio is 20:1 or more.

This means that Americans are eating and storing 11-20 times the amount of inflammation causing hormones (from vegetable oils and land animals) in comparison to the inflammation reducing hormones (from fish oils).

An AA/EPA ratio of 1.5:1 is considered ideal. This is the ratio found in Japanese populations which by the way have the highest life expectancy and the lowest rate of cardiovascular disease.

Our inflammatory reactions and their chemicals are therefore largely determined by what foods (fatty acids) we eat. Since most Americans are carrying around at least 10-20 pounds of excess fat, it is no wonder that arthritis and other inflammatory diseases are out of control in our country.

The average adult weighs 150 pounds, 30% of this is fat. This means that on average a person is carrying around 45 pounds of inflammatory fatty acid hormones!

Fish Oil Reduces Pain and Inflammation

Supplementing your diet with fish oils along with reducing the intake of arachidonic acid foods (land animals) can yield significant results.

Some studies have shown that supplementing with fish oils results in a dramatic reduction in a person’s leukotriens (one of the chemicals implicated in asthma) by 65%. This correlates with a 75% decrease in their clinical symptoms.

Stevenson, W.F. et al: Dietary supplementation with fish oil in ulcerative colitis. Ann Int Med 11:609-14, 1992.

Another fish oil study, involving rheumatoid arthritis sufferers (often treated with incredibly toxic and life threatening prescription drugs) who took 1.8 grams of EPA fish oil and reduced their saturated fats (land animal foods), showed significant improvement over and above a placebo.

Kremer J, Michaelek, AV, Lininger L et al. Effects of manipulation of dietary fatty acids on clinical manifestation of rheumatoid arthritis. Lancet 1985; i: 184-7.

Overcoming Chronic Fatigue Syndrome

A study investigating sufferers of the EBV particularly confirms this: Both eight and 12 months into the study, subjects who had recovered from the virus showed normal or near normal EFA (Omega 3) blood levels. In contrast, those who were still clinically ill from the EBV showed persistently low EFA levels.


Insufficient EFA’s (Omega 3) in the bloodstream can lead to fatigue. Consider one Scottish trial, in which patients with CFS were given Omega 3 supplements with great success. Placebo-controlled trials were held for 70 patients with persistent CFS, giving them linolenic acid (flax seed oil) and eicosapentaenoic acid (fish oil). After six months, 84% of the patients in the supplemented group rated themselves as “better” or “much better.” Only 22% of those in the placebo group reported such improvement. In another study of 63 adults with CFS, 74% of the patients taking EFA supplements, and 23% of those on placebo, assessed themselves as improved after one month.


Omega-3 fats work to keep us mentally and emotionally strong in three ways: They act as precursors for the body’s production of neurotransmitters (brain chemicals including serotonin); they provide the substrate for B vitamins (needed to make serotonin and other neurotransmitters) and coenzymes to produce compounds that regulate many vital functions (like CoQ10 and cellular energy production), and they nourish our nerve and brain cells. A deficiency in omega-3s is one of the main causes of depression and other mental disorders.

The psychiatric literature has recently published studies indicating that the prescence of major depression are associated with low levels of Omega 3 fatty acids.

“As with depression, heart disease is approximately fifty times more prevalent in nations with low levels of fish consumption as compared to countries at the top of the fish-eating scale.”

Andrew Stool, M.D. Harvard Medical School faculty and author of The Omega-3 Connection.

Increasing your cold water fish consumption is certainly a healthy step to take. However, for those concerned about the reports of mercury toxicity in cold water fish or who don’t like fish, you may want to consider taking a pure highly concentrated form of EPA fish oil.

 MARINE FISH OIL is available here

My INFLAMMATION FORMULA is available here

 I’m a firm believer in fish oil supplements. This is why my CFS/Fibromyalgia Formula has 2,000mg of fish in each day’s supply.

My CFS/FIBRO Formula is available here

Sleep deprivation and pain

One study showed that college students who were prevented from going into deep sleep (REM sleep) for a period of a week, developed the same symptoms associated with fibromyalgia (FMS) and chronic fatigue syndrome (CFS): diffuse pain, fatigue, depression, anxiety, irritability, stomach disturbances, and headaches.

P.Koch-Sheras and A. Lemley, The Dream Sourcebook ( Los Angeles: Loweel House)

A study conducted by the University of Connecticut School of Medicine compared the sleep patterns and associated symptoms of fifty women with FMS. The study showed that a poor night’s sleep was followed by an increase in the subject’s symptoms including, increased pain. The higher one’s serotonin level, the higher their pain threshold (less pain).

5HTP is available here

Avoid instant coffee

Instant coffee contains substances which block the receptor sites for endorphins.

Dr. Leon Chaitow, Fibromyalgia Workshop lecture 2000.

Arthritis Pain

Over 50 million Americans suffer from arthritis. It is associated with pain, stiffness, inflammation, and decreased range of motion. There are over 100 different forms of arthritis, but osteoarthritis is the most common.

Rheumatoid Arthritis

Rheumatoid arthritis is an autoimmune disease in which the body actually attacks itself. Antibodies develop in joint tissues and cause pain. Women are three times more likely to develop this arthritis than men. 1–3% of the population are afflicted.

What Causes It?

The definitive cause of rheumatoid arthritis is not known. It appears to result from a dysfunction in the autoimmune system.


Rheumatoid arthritis usually affects the knuckles, wrists, elbows, and shoulders with painful, warm, red swelling. Unlike osteoarthritis, which tends to be unilateral (one sided), rheumatoid attacks joints bilaterally (both sides).

Lab work

A normochromic (or slightly hypochromic)-normocytic anemia is found in 80% of cases.

The ESR is elevated in 80% of the cases.

Rheumatoid Factor is found in 70% of cases.


Only soft tissue swelling is seen in the first few months. Subsequently, periarticular osteoporis, joint space narrowing, and marginal erosions may be present.


In one study 70% of those with arthritis reported relief from chronic pain over a period of seven years after eliminating all white potatoes, tomatoes, peppers,(except black), eggplant, and tobacco.

Werbach M, Nutritional Influence on Illness (2nd ed) Third Line Press 1-800-916-0076.

• Hydrochlorhydria is associated with rheumatoid arthritis patients. Hydrochloric acid is needed for proper digestion, so individuals with known allergies, including arthritis, asthma, eczema, and psoriasis, should supplement their diets with 400–800 mg. of hydrochloric acid before each meal, but not if you suffer from peptic or gastric ulcers.

Werbach M, Nutritional Influence on Illness (2nd ed) Third Line Press 1-800-916-0076.

DIGESTIVE ENZYMES are available here - For Bloating, Gas, and Indigestion

• Zinc deficiency is common in rheumatoid arthritis patients. And the worse the inflammation, the less zinc seems to be in the blood. Supplementing with zinc may help relieve the pain, swelling, and stiffness. White spots on your finger nails is a sign of a zinc deficiency.

Pandley SP, Bhattacharya SK, Sundar S. Zinc in rheumatoid arthritis. Indian Jour of Med Res 1985; 81: 618-620.

• Malnutrition plays a role. Nearly three-fourths of Alabama rheumatoid patients were shown to be suffering from malnutrition. Compared to other individuals with musculoskeletal disorders, those with rheumatoid arthritis were significantly malnourished. This suggests that individuals with rheumatoid arthritis are not properly digesting their foods.

My ARTHRO FORMULA is available here


Sometimes wear and tear of the boney cartilage of the body causes bone spurs or calcium deposits to form on the ligaments surrounding the joint. This leads to inflammation, pain, and decreased joint motion. This is osteoarthritis. Osteoarthritis (OA) is also known as degenerative joint disease (DJD). OA first appears asymptomatically in the 2nd and 3rd decades becomes universal by the age of 70. Almost all persons by the age of 40 have some signs of OA in their weight-bearing joints, but only a minority, report any symptoms.

Surveys show that over 40 million Americans have OA.

OA sites - the peripheral joints, notably the distal and proximal interphalangeal joints (DIP and PIP joints respectively). The deformity of these joints causes Heberden’s and Bouchard’s nodes. Other joints include 1st metacarpal, cervical spinal, lumbar spinal, hip, 1st metatarsal phalangeal, knee joints, and the intervertebral disc.

Diagnosis- Initially OA is non-inflammatory and onset is subtle and gradual, usually involving one or two joints. Pain is the first symptom and is usually made worse by physical activity. Morning stiffness usually improves as the day goes on only to return again in the evening.

Lab work-

ESR may be normal or slightly elevated.


1. Irregular or asymptomatic narrowing of the joint space

2. Increase in radiologic density of the suchondral bone

3. Formation of osteophytes at the periphery of the joints

4. Formation of pseudo-cysts in the subchondral marrow.

What Causes Osteoarthritis?

Osteoarthritis is usually caused by trauma or joint injury (wear and tear). Many of my patients can trace the onset of their arthritis to a car accident, but some don’t remember anything that could be causing their neck or low back pain.

Some individuals develop osteoarthritis from repetitive motions, poor posture, or from simply carrying more weight than their joints can handle. Losing weight can often provide dramatic relief to those with weight-bearing osteoarthritis of the knees and hips. That’s because these joints bear loads 2.5–10 times a person’s weight. For a 200-pound individual, this can translate to one ton of pressure.

Heredity also plays a role in osteoarthritis.


Osteoarthritis is characterized by early morning stiffness or pain that eases up as the day goes on, only to return again in the evening. This form of arthritis generally affects the joints of the knees, hands, feet, and spine. It develops gradually over several years and usually doesn’t cause joint redness, warmth, or swelling like rheumatoid arthritis.

Traditional Arthritis Treatments

Nonsteroidal anti-inflammatories (NSAIDs) such as Bextra, Mobic, Ibuprofen, Daypro, Naprosyn, Celebrex, and Vioxx can cause intestinal permeability. They cover up the symptoms but do not address the cause, and they can actually cause further joint destruction.

Shield MJ. Anti-inflammatory drugs and their effects on cartilage synthesis and renal function. Eur J Rheumatol Inflam 1993; 13:7-16.

NSAIDs actually increase the acceleration of osteoarthritis and increased joint destruction.

Brooks PM, Potter SR, Buchanana WW. NSAID and osteoarthritis help or hinderence. J Rheum 1982; 9: 3-5.

According the FDA, over 200,000 people develop serious gastric bleeding and 10,000-20,000 people die every year from NSAIDs.

Drs. Peter M. Brooks and Richard O. Day, New England Journal of Medicine, 1991; 324(24):1716-25

Corticosteroids are strong hormonal drugs that can have serious side effects: peptic ulcer, osteoporosis, diabetes, glaucoma, depression, acne, water retention and weight gain, insomnia, facial hair growth, hypertension, and depressed immunity.

Methotrexate is an immune-suppressing drug used to treat psoriasis, psoriatic arthritis, adult and juvenile rheumatoid arthritis, and Reilers disease. It is a toxic therapy that can cause kidney failure and severe liver damage.

Gold injections can cause serious side effects: damage to the liver and kidneys, stomach disorders, anemia, headache, neuritis, and ulcerations of the mouth and gums.

Hypothyroid and osteoarthritis

Patients with hypothyroid have been shown to be at increased risk of developing osteoarthritis.

Bland JH, Cooper SM. Osteoarthritis: a review of the cell biology involved and evidence for reversibility. Management rationally related to known genesis and Pathophysiology. Sem Arth Rheum 1984; 14: 106-133


Nutritional Supplements

 DL-Phenylalanine and pain control

This is a combination of the D and L form of the amino acid phenylalanine. 

This form of phenylalanine acts as a natural pain-reliever. DL-phenylalanine blocks the enzymes responsible for the breakdown of endorphins and enkephlins. Endorphins and enkephlins are a group of substances within the body that help relieve pain. Endorphins are actually far more powerful than the drug known as morphine. Small cells throughout the nervous system, brain, spinal cord, and nerve endings are able to produce these morphine-like proteins. It acts as an appetite suppressant and mild stimulant. Although caution is advised for individuals with high blood pressure, DL-phenylalanine is an affective supplement in treating musculoskeletal pains, including those associated with FMS.  Many of my Fibromyalgia and chronic pain patients have benefited from taking DL-Phenylalanine. A clinical study shows subjects taking DL-phenylalanine had a remarkable improvement in their condition. Improvements were seen in 73 percent of low back pain suffers, 67 percent with migraines, 81 percent with osteoarthritis, and 81 percent with rheumatoid arthritis according to J. Brawly, pg. 131, The Food Allergy Revolution. For pain control, or as an antidepressant, take 1,000-4,000 mg twice a day on an empty stomach. Phenylalanine can elevate blood pressure and very high doses can cause rapid heart beat. Start with a low dose and increase to higher doses only as needed–and only if no side effects are noticed.

DL-PHENYALANINE is available here

Glucosamine sulfate is an excellent approach to eliminating the destruction of osteoarthritis. A growing body of research supports the use of this natural supplement.

1. Studies done in Milan, Italy, showed that glucosamine reduced arthritis symptoms by one half in 73% of the group, and 20% enjoyed total symptom relief.

Source: The Arthritis Cure by Jason Theodosakis et al, 1997


2. A study of patients with osteoarthritis of the knee, performed at the National Orthopedic Hospital in Manila, Philippines, showed that patients who were administered glucosamine had an 80% reduction in pain.

Other studies have demonstrated that glucosamine is more effective than ibuprofen (Motrin, Advil, or Nuprin) in relieving the symptoms of osteoarthritis.

 Source: The Arthritis Cure by Jason Theodosakis et al, 1997

Glucosamine is not only superior to nonsteroidal anti-inflammatory drugs such as ibuprofen, it is also free of the side effects of most arthritic medications. More importantly, glucosamine and chondroiten sulfate actually slow or arrest the destruction of cartilage.

Glucosamine, which is made up of glucose and the amino acid glutamine, actually helps repair damaged articular joint tissue. It does this by stimulating collagen cells within the articular cartilage to produce more proteoglycans. Proteoglycans are responsible for forming a protective netting within the articular cartilage, which helps prevent its destruction.

Glucosamine is not only superior to non-steroidal, anti-inflammatory drugs, it is also free of the side-effects that are associated with most arthritic medications. 

Dosage is 500 mg. three times daily. Your patients should see improvement in three–four weeks.

 • Chondroiten sulfate is composed of a large number of sugar molecules. It attracts fluid into the proteoglygan molecules, and this fluid acts as a shock absorber. Chondroiten inhibits certain enzymes that can damage cartilage, while stimulating the production of proteoglycans and other molecules needed for healthy new cartilage growth.

1. Studies performed at the University of Genoa, Italy, show chondroiten sulfate to be an effective therapy in eliminating the pain and stiffness associated with osteoarthritis.

Source: The Arthritis Cure by Jason Theodosakis et al, 1997


2. Another study, this time in France, showed patients who received three months of chondroiten therapy had actually repaired a significant portion of their degenerated joint tissues.1

Source: The Arthritis Cure by Jason Theodosakis et al, 1997

Dosage is 800–1,200 mg. daily. Your patients should see improvement in three to four weeks. Treatment should continue for a minimum of three months and, since there are little or no side effects, long-term therapy might be advisable.

My ARTHRO FORMULA Contains Glucosamine Sulfate and Chondroiten Sulfate and much more!

• Niacin (vitamin B3) may decrease the pain associated with osteoarthritis, especially in the knee. Dr. Abram Hoffer, author of Orthomolecular Medicine For Physicians,2 writes: “I suspect vitamin B3 is necessary for everyone for tissue repair, and that one of the earliest symptoms of deficiency is a decrease in the rate of repair.” Begin with 100 mg. daily, and slowly increase until one gram three times daily can be tolerated.

Caution: high doses of timed release niacin can cause nausea, flushing and elevated liver enzymes, though elevated enzymes caused by high niacin are not a concern, according to Dr. Hoffer.

• Boswelia: one of the oldest herbs in Indian ayurvedic medicine. Studies show it to be a potent pain-relieving anti-inflammatory. Boswellia helps shrink inflamed tissue, build cartilage, increase blood supply, and repair damaged blood vessels.

Recommended dose is 200-400mg a day.

Singh GB, AtaL CK. Pharmacology of ab extract of salai guggal ex-Boswellia serrate, a new non-steroidal anti-inflammatory agent. Agents Action 1986; 407-412

Reddy CK, Chandrakasan G, Dhar SC. Studies on the metabolism of glycosaminoglycans under the influence of new herbal anti-inflammatory agents. Biochemical Pharm 1989; 20: 3527-3534

• Bromelain: a protein-digesting enzyme derived from pineapple. There is considerable research (over 200 medical journal articles) on its effectiveness in treating such conditions as inflammation, pancreatic insufficiency, and respiratory diseases. It blocks inflammatory chemicals called kinins. It also digests excess fibren, a chemical implicated in osteoarthritis, sciatica, ankylosing spondylitis, and scleroderma. As an anti-inflammatory, bromelain needs to be taken on an empty stomach. If taken with food, it acts as a digestive enzyme.

Cohen A, Goldman J. Bromelain therapy in rheumatoid arthritis. Penn Med J 1964; 67: 27-30

Recommend dose is 1,800-2,000 m.c.u. or 125-450mg three times a day on an empty stomach.


• Curcumin: a perennial plant found in eastern Asia and parts of India. It is a popular arthritis remedy in India and a powerful pain-relieving anti-inflammatory. It is as strong as hydrocortisone without the side effects.

Recommended dose is 400-600mg three times a day.

Scimal R and Dhawan B. Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent. J Pharm Pharmac 25:447-52, 1973.


• Devil’s Claw: a perennial vine native to South Africa. It is a potent anti-inflammatory and pain reliever. Studies in Germany have shown this herbal medication to be very effective in relieving lower back pain and associated sciatica.

Brady LR, Tyler VE, Robbers JE. Pharmacognosy. 8th edn. Philedelphia, PA: Lea and Febiger. 1981: p 480



• S-adenosyl-l-methionine (SAMe) comes from the amino acid methionine and acts as a natural anti-inflammatory and blocks pain without the side effects associated with NSAIDs.

SAMe helps boost serotonin and epinephrine levels. It also helps increase the production of endorphins. Endorphins are the bodies natural pain blocking chemicals and are more powerful than morphine.

SAMe helps manufacture and repair cartilage components. A study of osteoarthritis patients compared SAMe with NSAID drugs in its ability to reduce pain.

One double-blind study showed SAMe was superior to ibuprofen in the treatment of osteoarthritis.

Glorioso S, Todesco S, Mazzi A et al. Double-blind multicentre study of the activity of S-adenosylmethionine in hip and knee osteoarthritis. Int J Clin Pharm Res 1985; 5: 39-49

Several studies involving SAMe and fibromyalgia patients yielded substantial improvement in over all pain levels (as well as depression).

Bendetto P Di, Iona LG, Zidarich V. Clinical evaluation of s-adenosyl-L-methionine versus transcutaneous electrical nerve stimulation in primary fibromyalgia. Current Ther Res 53(2);22 1993.

Jaccobsen S, Danneskiold –Samose B, Anderson RB. Oral  s-adenosyl-L-methionine in primary fibromyalgia. Double-blind clinical evaluation. Scandinavian Journal of Rheum 20(4): 294-302, 1991.


Dosage is up to 1,200 mg. taken on an empty stomach each day.


SAMe is available here


Malic Acid is found in a variety of foods. It is a vital nutrient needed for the production of cellular energy (Krebs cycle). Malic acid helps boost cellular energy and reduce achy muscles. It removes unwanted waste material from muscle cells including lactic acid, a byproduct of oxygen deficiency. Lactic acid has been implicated as one reason for achy muscles. Lactic acid may accumulate in muscles after periods of anaerobic and aerobic exercise. It may also be involved in the trigger point pains associated with fibromyalgia.

“Malic acid gave subjective improvement within 48 hours in one study.”

Sherry Rodgers M.D., Pain Free in Six Weeks.    


Studies involving FMS patients who were taking magnesium and malic acid together showed dramatic reduction in pain levels that returned with in 24 hours of discontinuing the supplements.

Abraham GE, Flechas JD. Hypothesis: Management of fibromyalgia: rationale for the use of magnesium and malic acid. J Nutr Med 3:49-59, 1992

This is why I have put high doses of both magnesium and malic acid in my CFS/Fibromyalgia Formula.

My CFS/FIBRO Formula is available here


I now have a 2 CD Set with me speaking called "Beating Pain." This 2 hour CD covers it all in detail - fibromyalgia, rheumatoid, osteoarthritis, and more. Great for listening to in your car or on your home stereo's CD player.

Subjects I cover on the two CDs...

My protocols for reducing and eliminating pain and inflammation.

The latest scientifically proven, cutting edge, nutritional supplements and how you can benefit from taking them.

How our diet affects our body’s own pain blocking chemicals.

How to turn off pain by changing the foods we eat.

Many individuals suffer from intestinal permeabilty and every time they eat they create more inflammation. I discuss how to correct this.

Some individuals have food allergies that cause their pain. I discuss which foods are most likely to cause pain and inflammation and how you can get major pain relief by simply avoiding a few foods.

This tape is loaded with two hours of clinical expertise. Learn all you can about your chronic pain and how to eliminate it naturally.

Normally $34.95

Now on sale for a limited time

A two-CD set for $25.95 + shipping

Available Here


Read some of the testimonials from people just like you who’ve benefited
from my book, protocols, and the products I recommend.

Many of you have written to thank me for my ongoing work with Fibromyalgia and CFS. I appreciate your encouragement. Your support is never more appreciated than when I encounter disbelieving doctors, skeptical patients, and the hopeless.

I want to give you three free chapters from my book, "Treating and Beating Fibromyalgia and Chronic Fatigue Syndrome." I want to share the things I've learned over the last 8 years. These chapters are in an easy-to-download pdf format. Please feel free to send this email, and these free chapters, to family and friends who either have the illness or who need to understand what you’re going through. This link also takes you to my archive of recent newsletters where you will find even more free information about these illnesses and treatments.

 Click here for three free chapters and access to my newsletter archives

Visit my website @ www.DrRodger.com

Dr. Rodger H. Murphree
3401 Independence Drive Suite 121
Homewood AL 35209

To set-up phone or office consults,
Call Dr. Murphree's office directly - toll free @ 1-888-884-9577.
Birmingham, Alabama USA.

Dr. Rodger Murphree's Email Address:


Source: The Arthritis Cure by Jason Theodosakis et al, 1997


For Further Reading

• Arthritis by Anthony Di Fabio, MA and Gus J. Prosch, Jr., MD; 1997

• Functional Assessment Resource Manual, Great Smokies Diagnostic Laboratory; 1999

• Textbook of Natural Medicine by Joseph E. Pizzorno, ND, (ed.) and Michael T. Murray (ed.); 1999

• Prescription for Herbal Healing by Phyllis A. Balch; 2002

• Essential Fatty Acids in Health and Disease by Edward N. Siguel; 1995

• Eating Well For Optimum Health by Andrew Weil; 2001

• Orthomolecular Medicine for Physicians by Abram Hoffer; 1997

• Dr. Braly's Food Allergy and Nutrition Revolution by James Braly, MD; 1992